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It comprises the references that were reported by the trial co-ordinating centres and those which are referenced in this information service, for example by the patient information texts. We here report the long-term outcome after a median follow up of 7. Seventy-two relapses and three second malignant neoplasms were reported. Survival after relapse was not related to biological factors and was very poor despite several patients receiving intensive treatments. Exploration of new drugs is warranted, preferably based on tumour biology from biopsy of the relapsed tumour.

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