Circadian clocks are present in all cells of the body, and have a pervasive influence on all aspects of human physiology. This is because they regulate homeostasis by anticipating rhythmic changes in behavior and nutritional state, and by compartmentalizing incompatible metabolic pathways within precise temporal windows. For example, it is known that shift workers are particularly susceptible to metabolic diseases such as diabetes. In their recent work, the team led by Uhlenhaut turned their attention to the hour metabolic rhythm of muscles. Building upon previous studies, the scientists studied the synthesis and breakdown of fats and proteins over 24 hours — an approach that might also be interesting for athletes.
How do muscles know what time it is?
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